On the variability of hemocoagulation system parameters under the separate and combined action of toxic substances
DOI:
https://doi.org/10.32523/hhx5yd59Keywords:
experimental animals, indicators of the hemocoagulation system, a complex of toxic substancesAbstract
The East Kazakhstan Copper and Chemical Combine is located in the Ust-Talovka settlement in the East Kazakhstan region. The structural units of the combine are three quarries (Shemonaikha, Nikolaevsky, Kamyshinsky) and the Nikolaevskaya processing Plant. In the open-pit mining process, all major processes are accompanied by the release of dust. During drilling, dust is released due to the destruction of rock or ore and the intake of drilling fines released from wells into the air. From the point of view of the danger and toxicity of polymetallic dust floating in the air of quarries and cabins of mining vehicles, the chemical composition of dust is of particular interest and attention. The works of A.A. Mamyrbaev show the presence of dust of a large number of potentially dangerous trace elements, lead nitrate, sodium selenate, arsenic oxide, and antimony oxide. The nature of the general toxic effect of these toxic substances has been studied in detail and summarized in numerous works; at the same time, the features of the specific effect of these substances on the activity of the blood coagulation system remain unexplored.
The aim of the study was to study the effects of toxic substances (lead nitrate, sodium selenate, antimony oxide, and arsenic oxide) in model experiments on animals.
Studies of the hemocoagulation system were conducted experimentally on white sexually mature male rats of the Wister line weighing 150-160 grams.
To assess the functional state of the rat blood hemocoagulation system, the following coagulogram tests were performed: fibrinogen concentration, prothrombin index, recalcification time, kaolin time, plasma tolerance to heparin, and an ethanol test characterizing the first, second, and third phases of the blood coagulation process.
The value of the study lies in the fact that the study of the adverse effects of industrial factors, namely, toxic substances, on various components of the blood coagulation system has not been conducted before, and the conducted research may clarify some controversial issues of modern coagulology.
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Copyright (c) 2026 Кульзипа Дакиева, Гульфат Калелова, Санат Кумарбекулы, Серик Бакин, Светлана Гармашова, Валерий Седелев, Роза Бейсембаева, Анатолий Цыганов (Автор)
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